Downstream processing of amorphous solid dispersions into tablets

Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with drug-polymer miscibility is major challenge in the downstream processing of ASDs. While many techniques are available converting ASDs into final dosage forms, oral solids remain most viable. The type excipients used conversion tablets very similar to conventional tablets. For example, binders widely polymeric carriers case physical properties manufactured using spray drying or hot melt extrusion pose current review focuses on various challenges and provide comprehensive manufacturing